After a few months of using an injectable prescription for weight loss, the first change Claire Nansikombi noticed was not physical but mental.
She had long struggled with food noise, but for the first time in her life, thoughts about food no longer dominated her mind. ‘Suddenly I was not constantly thinking about what I had eaten, should not eat, wanted to eat, or how much self-control I needed to get through the day,’ she says as she describes the past year of using Mounjaro as the best 12 months of her life.. ‘My energy levels are higher and the brain fog that once clouded my days has lifted. Some people will laugh when I say this, but the sky looks bluer, the air feels fresher and I wake up excited about possibilities again.’
Life before weight loss
Before the weight loss, Nansikombi, a digital creator and entreprenuer popularly known as Claire on her socials, says she was carrying far more than extra weight. Her health was deteriorating as she was living with high blood pressure, prediabetes, chronic body aches and persistent fatigue. ‘My knees hurt, my back hurt, and everything felt harder than it should have,’ she recalls. Despite the physical struggles, she never saw herself as someone whose life was on hold. She was building businesses, raising her daughter, travelling and creating a life she loved. On the surface, everything looked successful but behind the scenes, Claire knew her health was not on the ideal path.
Finding solutions
When she started taking the injectable treatments in June 2025, Claire was looking for a solution. By then, she had already tried diets, calorie counting, and willpower and exercise programmes. ‘I chose Mounjaro because I had tried everything else and still had not solved the problem,’ she notes. She explains that while it may be easy for some people to lose a small amount of weight, losing 50 kilogrammes is an entirely different challenge. The final straw came after months of intense effort. She was exercising regularly, eating sparingly and doing everything she believed she was supposed to do. Then she stepped onto the scale. ‘I felt hopeful and convinced that all my hard work would finally show up. Instead, the scale said plus two kilogrammes,’ she recalls.
She did not overthink it.
‘I stared at it, picked up my phone, called the clinic, booked an appointment, paid for my first month and started the journey,’ she recalls. What the treatment offered, she says, was a way of addressing the biological aspects of obesity rather than relying entirely on self-control. ‘It feels surreal to have lost more than 50 kilogrammes in one year. I spent more than 20 years trying and failing to lose weight. Finally succeeding at 35 has been one of the most incredible experiences of my life,’ she says.
Unlike many people who struggle with significant side effects, Claire says her experience has been remarkably smooth. ‘Every now and then I get a mild tummy ache on injection day, but that is about it,’ she shares.
Beyond the injection
Claire is quick to point out that medication alone is not responsible for the changes. A strong support system played a major role. Her family encouraged her throughout the process. Her online community celebrated every milestone and the clinic guiding her treatment provided much more than prescriptions. ‘Education is one of the most valuable parts of the journey. Through nutritional counselling, I learnt how to eat balanced meals without starving myself or banning foods I enjoy,’ she explains, saying she still enjoys ice cream, cake, rice, sweet potatoes and posho.
The difference, she says, is that she now prioritises protein and understands how to build meals that support her health.
Psychotherapy also helped her develop a healthier relationship with food and build sustainable habits. Even exercise, something she once disliked, has become part of her daily routine. ‘I walk between 5,000 and 10,000 steps every day. At first I hated it, but now my evening walk is one of my favourite parts of the day,’ Claire says.
Mental and emotional shift
The mother of one says the benefits have extended beyond physical health. Her confidence and productivity have improved and she has regained mental space. ‘Being overweight felt like a second full-time job. I was constantly thinking about food, diets, failure and trying again,’ she says. That burden has disappeared, allowing her to focus more energy on her daughter, her business and the things that matter most. Still, she acknowledges that the journey has not been without challenges. The hardest adjustment has been psychological. Even now, she sometimes catches her reflection and feels surprised.
‘The body changes much faster than the mind. In my head, I am still 124 kilogrammes because my brain has not fully adjusted yet,’ she explains. Losing weight publicly has also attracted opinions from all directions. ‘Everyone has an opinion, and people are often very passionate about those opinions,’ she notes. Claire notes that, fortunately, she has never been one to live according to other people’s expectations. ‘I do what I want and everybody else adjusts,’ she says.
Easy path?
Losing 52 kilogrammes felt surprisingly achievable but required financial readiness. ‘Spending between Shs500,000 to Shs900,000 every month is not exactly effortless. I simply choose which hard feels easier,’ she explains, noting that she believes long-term success depends on building sustainable habits. Claire emphasises that the injections are not a casual treatment. She warns against counterfeit products and self-medication, noting that she has heard from people who encountered serious complications after trying to manage the process without professional guidance. ‘Mounjaro is a serious medication and should always be used under medical supervision,’ she stresses.
Rethinking risks
Claire observes that people spend a lot of time worrying about potential long-term risks, but very few people talk about the guaranteed risks of remaining obese. ‘If I had stayed where I was, I was looking at a future that included diabetes, hypertension, heart disease, declining mobility and a significantly reduced quality of life,’ she shares. When she weighed those realities against the possible risks, the choice became clear: ‘I was comparing guaranteed consequences with possible consequences. The decision made itself. ‘
For anyone considering medical weight-loss treatment, Claire recommends working with qualified medical professionals. ‘Do not attempt the journey alone. Use the medication as a tool rather than expecting magic. And use the time to improve nutrition, mindset and long-term habits,’ she advises. Most of all, she challenges the idea that struggle is somehow more noble. ‘Life is already hard enough,’ she says. ‘We deal with grief, trauma, family problems, financial stress, loneliness, illness, anxiety and countless other challenges every day.’
For her, effective medical support for obesity represented an opportunity she was no longer willing to ignore.
‘You do not get extra points for choosing the harder path,’ she says.