Rukungiri pastor arrested over alleged assault of church secretary

A pastor in Rukungiri District has been arrested after allegedly assaulting a church secretary during a dispute over money collected from worshippers, police said.

The suspect, identified as Felix Ayebare, is a pastor at Kyarusongyera Anointed Church in Bwanga Parish, Nyarushanje Sub-county.

Kigezi Regional Police spokesperson SP Nelson Tumushime said the incident occurred on August 30 at about 2pm at the church.

According to police, Mr Ayebare grabbed money from a collection basket before it had been counted, triggering a confrontation with Joan Byomuhangi, 34, the church secretary.

‘In the ensuing altercation, the pastor allegedly hit and boxed Ms Byomuhangi. He is also accused of grabbing her mobile phone and throwing it to the ground, leaving it cracked on both the front and back,’ SP Tumushime said in a statement dated September 4.

Police also allege that Mr Ayebare had earlier accused Ms Byomuhangi of preventing him from accessing church funds and had threatened her.

Tumushime said the suspect was arrested and remains in custody as investigations continue.

Police cautioned religious leaders against using violence or engaging in criminal activities under the guise of performing their religious duties.

‘Freedom of worship does not allow assault, fraud and extortion,’ Tumushime said, warning that religious leaders found engaging in criminal activities would be arrested and prosecuted in accordance with Ugandan law.

Women’s Leadership Resilience: From surviving the workplace to redesigning it

Let’s cast our minds back to Purl, Pixar’s short film about a young woman trying to find her place in a workplace that was not designed with her in mind. What struck me was not simply the story of a woman entering an unfamiliar environment, but what happens when she learns to survive in it. She changes the way she speaks, dresses, and behaves, gradually becoming more like the people around her in order to belong.

But the most powerful part of the story comes later. When another young woman arrives, Purl has a choice: does she reproduce the culture that taught her how to survive, or does she make the workplace different for the woman coming behind her?

She chooses the latter. The younger woman does not have to become someone else to fit in. She can wear pink. She can keep her voice. She can remain herself and still be taken seriously. Because someone before her held the door open.

I think this is an important question for women in leadership today, particularly now that we are asking more senior women to mentor, sponsor, and develop younger women. Many of the women who occupy senior positions today had to develop extraordinary resilience to navigate workplaces that were less flexible, less empathetic, and often designed around a very different model of leadership. We should absolutely pass on the resilience, judgement and stamina that helped us survive. But perhaps our responsibility is not to reproduce the hardship that produced those qualities.

That is where empathy becomes important. Not softness, lowering standards, nor shielding younger women from difficult work, but empathy. Where we say: I want you to develop the resilience I had to develop, but I don’t want you to experience every hardship I experienced.

I will stretch you, but I won’t break you; I will challenge you, but I won’t humiliate you; I will expose you to difficult decisions, but I won’t abandon you in them; I will expect accountability, but I will also give you the support and authority to succeed; and I will teach you how institutions work, but I will not teach you that dysfunction is the price of belonging.

Perhaps that is the tension we need to confront as one generation of women begins to lead and mentor another: what should we preserve from the leadership culture that built us, and what should we have the courage to change?

Resilient leadership is not burnout

Boards and management have a responsibility to create conditions where leaders are stretched by the work, but not systematically depleted by the organisation. There is a subtle but important difference between resilient leadership and burnout: one builds capacity; the other progressively erodes it.

And in our attempt to prevent burnout, we must be careful not to tip the balance too far in the other direction. Every difficult assignment cannot become ‘toxic.’ Every demanding period cannot automatically be labelled ‘burnout.’ We cannot shield people from the very experiences that develop judgement, stamina, adaptability and leadership capacity.

So the question is not whether leadership should be hard. The question is: what kind of hard are we creating? There is healthy pressure: demanding targets, difficult decisions, organisational transformation, crisis response, accountability and being stretched beyond what is comfortable. These are not necessarily signs of a dysfunctional workplace. Sometimes, they are precisely where leadership capacity is built.

Then there is dysfunctional pressure: chronic understaffing, poor systems, unclear authority, unrealistic expectations, persistent crisis management, inadequate succession planning and a culture of permanent availability. This distinction matters because resilience should not become an excuse for organisational dysfunction, just as wellbeing should not become an excuse for avoiding growth.

That, to me, is the real opportunity of women’s intergenerational leadership: to make the systems healthier while still preparing women to be strong leaders.

Redesign the Conditions, Not Just the Women

If we want women to build resilience without burning out, we have to examine the conditions in which leadership happens. Many workplaces were built around an old model of the ideal worker: always available, able to absorb additional responsibilities, comfortable operating under constant pressure, and largely unencumbered by responsibilities. The problem is not that women cannot succeed in such environments. Many have. The question is how many capable women have had to opt out, slow down, or leave because the cost of succeeding became too high. This is why resilience cannot simply mean teaching women to endure more. The organisation itself has to be designed to support sustained performance.

Start with workload and capacity. A demanding organisation is not necessarily a dysfunctional one. But when resilience is being used to compensate for poor organisational design. Boards should be asking whether workloads are matched to resources and whether high performers are being overused. A demanding season may be necessary; a permanently demanding organisation is a design problem.

Match responsibility with authority. If we want women to develop judgement, we have to give them room to exercise it. There is little developmental value in stretching a leader means giving her a difficult problem and allowing her to work through it; it does not mean giving her an impossible problem and calling the resulting exhaustion a resilience test.

Build recovery into the way work is designed. Recovery should not be something leaders access only after they have reached breaking point. Boards and management need to examine leave practices, meeting cultures, after-hours expectations, staffing levels and workload cycles. The objective is not to create a pressure-free workplace. It is to create a workplace where periods of intense pressure are followed by recovery rather than simply becoming the new normal.

Make support compatible with high performance. One of the things we must unlearn is the idea that asking for help signals that a leader is not capable. In reality, knowing when to seek expertise, escalate a problem or ask for additional resources is itself a leadership skill. Women should be given increasingly difficult challenges, but they should also have access to mentorship, sponsorship, feedback and the institutional support required to learn from those challenges.

And this is where intergenerational leadership becomes particularly important. Senior women have an opportunity to pass on the resilience, judgement and stamina they developed without requiring younger women to reproduce every hardship through which they learned them. We can teach younger women how to handle difficult conversations, navigate institutional politics, make unpopular decisions and remain steady in a crisis. But we can also teach them that exhaustion is not a badge of honour, that dysfunction is not the same as high performance, and that asking for help does not diminish their leadership.

That is the redesign we should be aiming for: not workplaces that ask women to become less resilient, but workplaces that stop confusing resilience with endurance. The goal is to develop women who can withstand pressure, make difficult decisions and lead through uncertainty.

Final Thoughts

Perhaps this is where Purl becomes more than a story about women fitting into the workplace. It becomes a story about what happens when someone finally has enough power to make the workplace safer for the person coming behind her.

At the heart of that is psychological safety. A psychologically safe organisation is one where people can say: ‘I don’t know.’ ‘I made a mistake.’ ‘I disagree.’ ‘This isn’t working.’ ‘I need help.’ And still know that saying these things will not diminish their worth, their credibility or their future in the organisation.

For women in particular, this has an important intergenerational dimension. We should not pass down a version of leadership that says, ‘I survived it, so you should too.’ We can pass down the judgement, courage, stamina and institutional wisdom that experience gave us without passing down the dysfunction that once surrounded it.

To prepare the woman coming behind us is not simply for them to survive the workplace we inherited, but to have the resilience to lead, the safety to remain herself, and the opportunity to make the workplace better for the woman who comes after her.

Understanding peer influence in marketing

Peer influence is how the behaviour of the people around us impacts our own behaviour. Though the influence of peers on our behaviour peaks at age fourteen, people around us continue to impact our behaviour our entire lives. When it comes to marketing, purchasing is the behaviour that marketers try to influence, as well as the actual use of the product. Therefore, peer influence in marketing is how the behaviour of others influences our likelihood to buy and use a product.

Peer influence is what often compels us to copy, comply, and try to impress the people around us, in turn affecting what brands we buy, wear, or use.

Simply put, peer influence is when the behaviour(s) of others in our environment affects our own behaviour. Peer influence can be approached from a variety of broad angles, such as when a peer asks us to do something, when we change our own behaviour to match the behaviour of a peer that is being rewarded (or the opposite), or we can also change our behaviour to impress or distance our peers.

Some of this behaviour change is conscious, like making an active choice to agree to a friend’s request or to buy a product on someone’s recommendation, but most of it is subconscious; our brains are working in the background leading us to act in ways that will preserve or improve our social status with our peers. It is a survival mechanism for social animals like us.

Conformity is how we adjust our behaviour or thinking to match the practices or rules of a group that we belong to. An example of conformity is when we dress, do our makeup, and/or style our hair in a way that is similar to the way others in our peer group are. When we conform, we may also fail to consider other viewpoints leading to the so-called ‘group think.’

Social norms

Social norms are at play when we let behaviour accepted as normal by our culture influence our behaviour. We drive on the right side of the road, have haircuts according to our gender, and carry a smartphone without even thinking about our actions because these are accepted, normal behaviours in our culture.

Peer pressure

Peer pressure happens when those participating in a common behaviour do not accept the different behaviour of someone outside the group and actively tries to get ‘the outsider’ to behave in ways that the main group does. We often hear about the many bullying examples of peer pressure, but even group members urging their friend to buy an iPhone so they can use iMessage is a form of peer pressure.

Peer endorsement

We all tend to do something more when our peers mention that they like it. This is peer endorsement: a behaviour is more likely to happen when our peers praise it.

Our brains get a rewarding hit of dopamine when one of our peers applaud our action(s). Now technology has taken peer endorsements to another level with likes, follows, shares, retweets, and a variety of other endorsements in social media.

Prathibha Liyanarachchi secures multiple top placements at 73rd Miss World

Sri Lanka’s representative at the 73rd Miss World pageant, fashion designer and model Prathibha Liyanarachchi, has secured multiple top placements in the fast-track rounds of the competition, strengthening Sri Lanka’s presence on the international pageant stage.

Competing against representatives from around 100 countries and territories, Liyanarachchi has placed in four major fast-track challenges.

She was named among the Top 24 in Beauty With a Purpose (BWAP), Top 23 in Talent, Top 24 in the Sports Challenge and Top 60 in Top Model.

The placements recognise her performance across a diverse range of challenges that form an important part of the Miss World competition. They also highlight Liyanarachchi’s ability to represent Sri Lanka beyond the traditional pageant platform, combining fashion, creativity, purpose and advocacy throughout her journey in Vietnam.

A fashion designer, model and founder of HOOP The Label, Liyanarachchi has built her Beauty With a Purpose project around the empowerment of underprivileged women in Sri Lanka through craft. Through HOOP, women artisans are provided with training, mentorship and income-generating opportunities, while their traditional and creative skills are developed into products with the potential to reach wider markets.

The initiative has become a central part of Liyanarachchi’s Miss World journey and was shortlisted among the Top 24 Beauty With a Purpose projects worldwide. It was also recognised among the top six representatives from the Asia and Oceania region, placing her work among a select group of purpose-driven projects presented at this year’s competition.

Beyond the competition itself, Liyanarachchi has used her time in Vietnam to promote Sri Lankan creativity and craftsmanship, wearing and carrying products created by local designers and artisans as she takes part in the various events and challenges.

‘I am incredibly proud to represent Sri Lanka on a global stage. Being part of the Miss World competition has always been a dream, and it is both an honour and a huge responsibility to represent my country here. I am delighted with these placements and will continue to work hard to make Sri Lanka proud,’ said Fashion Designer and Model Prathibha Liyanarachchi.

She said one of the most meaningful aspects of the experience had been the opportunity to meet women from different parts of the world and share Sri Lanka’s culture, creativity and talent. Through HOOP, she hopes to draw greater attention to the capabilities of Sri Lankan artisans while creating opportunities for women to build sustainable livelihoods through craft.

The 73rd Miss World pageant is currently taking place in Vietnam, bringing together contestants from around the world for a series of cultural, charitable, talent, sporting and fashion-related events ahead of the final.

The grand finale of the 73rd Miss World pageant is scheduled to take place on 5 September, 2026, in Nha Trang, Vietnam, where contestants will compete for the Miss World crown.

Azerbaijan’s digital push meets Trkiye’s tech boom along Middle Corridor

Turkiye’s economy grew by 2.3 percent year-on-year in the second quarter of 2026, a relatively modest figure in an economy still dealing with high inflation and tight monetary policy. One number in the GDP data, however, deserves considerably more attention: information and communication activities expanded by 8.6 percent.

The first point to understand is that ‘information and communication’ is broader than the traditional IT sector. It covers telecommunications, internet infrastructure, software, digital services, data centers and related activities. Turkiye’s sector has now recorded ten consecutive quarters of growth, with annual growth rates in the past four quarters ranging between 8.6 and 9.9 percent. The expansion has been supported by digital transformation, cloud services, data centers, artificial intelligence and major investments related to 5G.

That growth is important for Turkiye itself, but its significance goes beyond the country’s borders. For Azerbaijan and the wider South Caucasus, Turkiye’s expanding digital economy could become another channel of economic integration, alongside energy, transport and trade.

This matters because digital infrastructure increasingly determines how efficiently other parts of the economy operate.

Consider the Middle Corridor. Azerbaijan has spent years positioning itself as a transit country connecting Central Asia with Turkiye and Europe. Traditionally, the discussion has focused on railways, ports, highways and customs infrastructure. The next stage is likely to be digital.

Cargo moving through Azerbaijan and Turkiye generates enormous amounts of information: customs documents, invoices, shipment data, tracking information, insurance records and transport documents. If these systems communicate with each other, the physical movement of goods can become faster and more predictable.

Turkiye and Azerbaijan have already started moving in this direction. In 2026, the two countries launched work on an e-CMR pilot aimed at digitalizing cross-border freight documents. Such projects may sound technical, but their economic consequences can be quite practical. Less paperwork means fewer delays, lower administrative costs and better visibility for logistics companies.

Turkiye’s expanding telecommunications infrastructure strengthens this possibility. Turkish authorities reported that the country’s fiber network reached 697,000 kilometers in the first quarter of 2026, while total broadband subscriptions reached 99.5 million. Investments linked to 5G are also pushing demand for fiber, data centers and network capacity.

Azerbaijan is developing its own digital infrastructure at the same time. During the first half of 2026, 147 government institutions had migrated to the Government Cloud, while 140 private organizations were using data-center services. Azerbaijan also began construction of two additional data centers and expanded its fiber infrastructure.

Turkiye has a much larger technology market, a sizeable telecommunications industry and a growing base of companies developing software, cloud and digital services. Azerbaijan has a strategic geographic position between Turkiye, the Caspian Sea and Central Asia. Connecting these capabilities could create opportunities that neither country would capture as easily on its own.

One particularly interesting possibility is digital services exports. Turkish software, cybersecurity, cloud and business-technology companies could use Azerbaijan as a platform for reaching Central Asian markets. Azerbaijani companies, meanwhile, could benefit from Turkish technology, investment and access to a much larger commercial ecosystem.

The opportunity is already visible in Azerbaijan’s own numbers. In January-July 2026, the country’s information and communication services increased by 10.4 percent in real terms. Software development and related consultancy services grew by 34.8 percent, while internet services increased by 22 percent.

That suggests the relationship could become more balanced than a simple story of Turkish companies entering Azerbaijan. Azerbaijan itself is developing a digital-services industry that could eventually sell into Turkiye, Central Asia and other markets.

There is also a strategic dimension. Azerbaijan has traditionally derived much of its international economic importance from its position as an energy producer and transport corridor. Digital connectivity offers another layer to that position. A country through which physical goods, energy and data move has a different economic profile from a country that simply provides a route for cargo.

Still, it would be a mistake to assume that Turkiye’s 8.6 percent growth automatically benefits Azerbaijan. GDP growth in one country does not spill across borders by itself. The gains depend on investment, cross-border infrastructure, compatible regulations, technology transfers and companies actually using the new systems. The real opportunity is therefore not the 8.6 percent figure itself. It is what that growth is building: fiber networks, 5G infrastructure, cloud capacity, data centers, software capabilities and digital platforms.

For Azerbaijan, the strategic question is whether it can connect these developments to the country’s own ambitions for the Middle Corridor and digital economy. If it succeeds, the corridor linking China, Central Asia, the Caspian, Azerbaijan, Turkiye and Europe could eventually carry far more than containers and commodities, and data, digital services and technology as well.

Immaculate Acheng Otuko wins Femrite Youth Innovation Poetry Challenge 2026

Lira-based female writer won the youth innovation poetry challenge for 2026 held at Busitema University, Arapai Campus, Soroti.

Immaculate Acheng Otuko from Lira District won the young writers’ competition for 2026 organised by Uganda Women Writers’ Association (FEMRITE) themed Youths and arts for sustainable agro-ecological food systems. Her short poem, ‘What changed in the pot?’ was revealed as the best by the three sets of judges. The judges scrutinised a collection of more than 300 poems that Femrite received from across the country.

Otuko’s poem, What Changed in the Pot? uses the metaphor of the pot to portray what today gets out of our saucepans as food is served on our tables.

It makes a comparison of the chemical-laced foods from the farm that we feed on today with what it was before the food systems got adulterated by the current food chain systems.

Otuko, who walked away with the writer’s prize, certificate and Shs1m as winner for the youth innovation poetry challenge 2026, says her choice of the poem is based on the current realities that are hurting human health.

‘For the love of quantity and fast yields, the children now gobble chemicals in the name of food, mama says the beans don’t take long anymore, they soften too quickly, as if they have nothing left to resist,’ she shares.

Otuko, a teacher of English in Literature, says writing has been her hobby from Senior One, adding that over time she has accumulated a collection of poems to her name, ‘I grew up in the times of war and its resultant effect could have also shaped my view of the world around me,’ she adds.

The other poem, ‘What grandmother knew’ by Freddie Kayongo was recognised as the second best done. He walked away with shs500, 000 and a certificate from Femrite.

The third runners up in the competition jointly organised by Femrite, Stepup and McKnight foundation was Mark Wilson Muhindo from Kasese who authored ‘ Love the soil again’ walked away with shs300, 000, and certificate ,his poem revolves around the repeated use of chemicals and fertilisers while Aaron Dominic Omodo from Soroti also bagged Shs 300,000 and certificate for his poem ‘The red Tomato’.

The essence of competition

Ms Hilda Twongyeirwe, executive director of Femrite, said they received more than 300 poems from across the country but majority neither met the essence of the day because they were AI-generated nor the criteria for the competition.

She added, ‘As much as students may use AI, this should be for purposes of research but not passing exams. Don’t let AI use you. We were so strict that all AI-generated poems were detected, irrespective how beautiful they may have sounded.’

The beauty about writing, she said, is that it takes you into spaces that you have never been in physically. There is a lot to worry about in line with the compromised food systems, there is a lot of obesity in schools and the cancers that are taking us early.

‘As Femrite, we want to see how we can contribute to make our food and food systems sustainable,’ she explained, adding that the selection of Busitema University to host the award event was well-thought out, because they are championing development in agriculture.

To interest the youth to write about agriculture will ensure that we have sustainable food systems.

Rehema Eton, the deputy academic registrar Busitema University, Arapai campus, said there is a lot of research and publications that the university is doing, adding that the initiative by Femrite and her sister partners is a plus for them in creating awareness about the sustainable agro ecological food systems.

Femrite, together with her partners, states that over time, various changes have taken place in the farming sector, yet the human body, which is the recipient, has not changed.

Despite Uganda’s fertile soils, we are almost under siege from unsafe farm chemicals, an increased taste for processed foods, an indiscriminate appetite for improved seeds that may not be sustainable, use of unsafe oils, fats, and sugar, all of which could potentially lead to several challenges.

Who Leaves Banking for Make Up? – A review of Behind the Curtain Oke Maduewesi’s My Zaron Story A Leadership Story

Title: Behind the Curtain: Oke Maduewesi My Zaron Story A Leadership Story

Year of Publication: 2026

Number of Pages: 104

If you are a woman, there is a very good chance that Zaron has passed through your hands at some point. You may have used the powder, owned one of the brushes, tried the Matte Lip Fix, or stood in front of a Zaron display wondering which shade would finally make you look like you have your life completely together. Or perhaps you have simply heard the name Oke Maduewesi and wondered, Who exactly is this woman behind Zaron? Well, this book answers that question and quite a few others.

Women in the beauty business will probably grab this book with both hands the moment they see it. But this is not just for women who know their concealer from their contour. If you are thinking of starting a cosmetics business, building a brand, or simply curious about what it really takes to build a successful business from scratch, you should be paying attention.

Reading this book feels a little like sitting in a business meeting with Oke and discovering that she has decided to hand you her private notebook. Thankfully, there is no ‘I believed in myself, followed my passion and everything magically worked out’ nonsense here. Oke tells her story as it happened, with the good, the bad, the uncomfortable and the lessons in between.

Before taking you into the world of Zaron, she introduces you to Oke the woman. She talks about her personality, her family, her experiences and even some of the ways people may have misunderstood her. It is almost as if she is saying, ‘Before you judge me, let me first explain myself.’ Then she gets down to business.

From banking to makeup to skincare, Oke takes you through the decisions, risks and challenges that shaped her journey. For anyone considering the cosmetics business, the book offers a valuable shortcut through years of trial and error, packing practical experiences into a relatively small book.

Some of the stories may sound familiar because you may have heard parts of Oke’s journey before. You may even feel sorry for her at certain points, but pity is not what she is after. She is more interested in showing you what happened and what she did with those experiences.

And then there is the fascinating revelation that the name Zaron was inspired by her children’s names. Yes, her children! Imagine discovering that the names you gave your children would one day become part of a beauty brand known across Nigeria. That is certainly one way to get the whole family into the business story.

One thing you cannot miss about Oke is that she knows herself. She knows what she wants, what she is good at and what she is willing to risk. There is something admirable and sometimes slightly intimidating about a woman who is that sure of herself.

Then she leaves her banking job. Without a Plan B. Who does that? Please, before you start typing your resignation letter because Oke did it, calm down. This is not your cue to resign tomorrow morning and announce that you are following your passion. Oke knew her strengths, and your strengths are not necessarily hers. She was also very conscious of what she was giving up, including the comfort and security of a banking career.

There is a quiet strength about Oke. She comes across as confident and strong, yet calm and peaceful at the same time. It is an interesting combination, and one that makes her story even more fascinating.

Her experiences with grief add another dimension to the book. You see how loss can change the way a person thinks, sees life and even approaches business. It becomes clear that Zaron is not simply a cosmetics brand; it is also part of a much bigger personal journey.

Her humility also comes through strongly. She says it herself, but more importantly, the woman she describes on these pages seems to be the same woman you encounter in real life. If you have met her, you can probably testify to that.

Ultimately, this is more than the story of a woman who built a successful Nigerian beauty brand. It is a candid account of ambition, risk, resilience and the courage to keep learning.

Oke has put many of the lessons she gathered along the way on the table. The least you can do is take notes.

About the reviewer

Titilade Oyemade is a business executive in a leading organisation and holds a degree in Russian Language. She’s the convener of the Hangoutwithtee Ladies Event and the Publisher of Hangoutwithtee magazine. She spends her weekends attending women conferences, events and book readings. She loves to have fun and to help other women have the same in their lives. Email: titi.oyemade@gmail.com Social: @tiipreeofficial

Roche’s alzheimer’s drug clears plaques in 28 weeks, faces 2028 test to slow memory loss

Roche’s experimental Alzheimer’s drug, trontinemab, has cleared harmful protein deposits from the brains of nine out of 10 patients within 28 weeks, giving fresh hope in the search for treatments that can slow memory loss.

Alzheimer’s disease is a condition that gradually damages the brain and makes it harder for people to remember things, think clearly and carry out everyday activities. One of the things that happens in the brains of people with Alzheimer’s is that a protein called amyloid builds up and forms sticky clumps, known as plaques.

These plaques can damage brain cells over time. Trontinemab is designed to help the body remove these plaques from the brain. In simple terms, the drug acts like a guided clean-up system, helping the brain’s natural defence cells find and remove some of the harmful protein deposits.

Roche reported the 28-week result from its Phase 2 trial in July 2025. The study involved about 100 people with early-stage Alzheimer’s disease or mild cognitive impairment.

The result was striking in that, about 90 percent of the patients had their amyloid plaques cleared within 28 weeks.

But there is an important question that the trial could not answer: Does removing the plaques actually help people keep their memory for longer?

That is what Roche is now trying to find out.

The big test comes in 2028

Roche has moved trontinemab into larger Phase 3 clinical trials, with each of the initial trials expected to enrol about 800 people.

The trials are designed to determine whether the drug can actually slow the decline in memory and thinking among people with Alzheimer’s disease.

Results are expected in 2028. This will be a much more important test of the drug than simply showing that it can remove amyloid.

Removing the plaques is encouraging, but it does not automatically mean that a person’s memory will improve or that Alzheimer’s will stop getting worse.

The 2028 results will show whether the biological change seen in the brain can translate into a real benefit in people’s daily lives.

How does the drug reach the brain?

Getting an Alzheimer’s drug into the brain is not easy. The brain has a natural protective barrier called the blood-brain barrier. It keeps many harmful substances in the blood from getting into brain tissue, but it can also prevent useful medicines from reaching where they are needed.

Roche designed trontinemab with a technology called Brainshuttle, which is intended to help the drug cross this barrier more easily.

Once inside the brain, the drug attaches itself to amyloid beta, the protein that forms the plaques. This helps the brain’s immune system identify and clear the deposits.

The idea is therefore not simply to put more medicine into the bloodstream, but to make sure more of the medicine can actually reach the brain.

Why this matters

Current Alzheimer’s treatments can help manage symptoms, but disease-modifying drugs such as trontinemab are being developed with a goal to slow the underlying disease process itself.

Other drugs, including lecanemab and donanemab, also target amyloid plaques. Roche is hoping that trontinemab’s ability to cross the blood-brain barrier more efficiently can improve the way this type of treatment works.

The company is also testing the drug much earlier in the disease process.

One Phase 3 trial is looking at people who do not yet have dementia symptoms but have high levels of a blood marker called p-tau217.

P-tau217 is a protein marker that can help researchers identify changes linked to Alzheimer’s disease before serious symptoms appear.

The thinking is that treating people earlier, before extensive damage has occurred, could potentially delay or prevent the point at which memory problems become noticeable.

Safety still needs to be watched

Like other drugs that target amyloid, trontinemab can cause a side effect known as amyloid-related imaging abnormalities, or ARIA.

ARIA can cause swelling or tiny areas of bleeding in the brain. Doctors can usually look for these changes using MRI brain scans.

In the Phase 2 trial, four people, though less than five percent of participants, showed signs of ARIA on their brain scans. Only one person developed symptoms, and those symptoms were mild.

The larger Phase 3 trials will provide more information about how safe the drug is when used in a much larger group of people.

For now, trontinemab remains an experimental treatment and is not yet an approved cure for Alzheimer’s disease.

Its early results, however, point to a potentially important development in the fight against the disease.

The real test will come in 2028. That is when researchers hope to answer the question that matters most to patients and their families: whether clearing the plaques can help people keep their memory and thinking abilities for longer.

Sri Lanka’s young sevens teams ready for Asia Under-18 Championship in China

Sri Lanka’s boys’ and girls’ rugby sevens teams are set to compete in the Asia Rugby Under-18 Sevens Championship, which will be played in China today and tomorrow, with the country’s rising stars aiming to make their mark against the continent’s best young talent.

The boys’ tournament features nine teams divided into two groups. Sri Lanka has been drawn in a challenging Group A alongside Hong Kong China, Malaysia and India, while Group B consists of hosts China, Chinese Taipei, Kazakhstan, Uzbekistan and the UAE.

The Sri Lankan boys’ outfit will be captained by Mohamed Fawaz and coached by Rajeew Perera, with Bhanuka Nanayakkara serving as assistant coach and Imran Thalagampe as team manager.

The side will be looking to produce strong performances against experienced regional rivals and challenge for a place in the knockout stages.

The girls’ competition will feature eight teams split into two groups. Sri Lanka is placed in Group C with China, Kazakhstan and Uzbekistan, while Group D includes Hong Kong China, India, Malaysia and the UAE.

Ayusha Jeewamani will lead the Sri Lankan girls’ team under the guidance of head coach Shamly Nawas, assisted by Asela Deshapriya, with Thilini Senanayake serving as team manager. (SJ)

Boys

Group A: Hong Kong China, Malaysia, India, Sri Lanka

Group B: China, Chinese Taipei, Kazakhstan, Uzbekistan, UAE

Girls

Group C: China, Kazakhstan, Uzbekistan, Sri Lanka

Group D: Hong Kong China, India, Malaysia, UAE

Kusal Mendis ruled out of England T20I series, Asalanka to captain

Kusal Mendis who was named captain for the two white ball series in England has been ruled out of the three-match T20I series along with left-arm fast bowler Binura Fernando.

Both players are recovering from injuries and have yet to prove their fitness by playing in a match.

Charith Asalanka who was named vice-captain for the T20I and ODI series will lead Sri Lanka in the three T20I matches against England commencing 15 September at Southampton. The second and third matches will take place at Cardiff (17 September) and Manchester (19 September).

Asalanka returns to the T20I captaincy after being ditched from the job for a combination of poor form and his hesitance to play on during Sri Lanka’s tour of Pakistan last year citing security concerns.

Mendis and Fernando have been replaced in the 16-member squad by Pavan Rathnayake and Dilshan Madushanka. Both these players were named in Sri Lanka’s ODI squad to England, but will now have the opportunity to play in both formats.

By naming Mendis captain for England as it was pointed out in these columns, the selectors were taking a gamble as he had not conformed to their policy of playing in a match before being considered for selection coming back from an injury.

Saner counsel seems to have prevailed and Mendis has been quite rightly been kept behind to prove his fitness at least before the three-match ODI series which commences on 22 September.

Mendis suffered a right hamstring injury during the Lanka Premier League (LPL) and has been undergoing rehabilitation at the High Performance Centre (HPC). He is expected to play for SSC in the Major Club 50-over and T20 tournaments next week.

Fernando, who sustained a back injury during the LPL, has also been undergoing rehabilitation at the HPC and has not played a match yet. As he is part of only the T20I squad he will miss the tour to England.

Sri Lanka’s T20I squad will leave for England today with the ODI squad due to follow on 18 September.

Asalanka, Dasun Shanaka, Wanindu Hasaranga and Maheesh Theekshana are due to join the T20I squad in England from the Caribbean where they are currently taking part in the Caribbean Premier League (CPL).

Shanaka set ablaze the CPL on Thursday, by slamming the fastest century in the tournament’s history – off 39 balls for St Kitts and Nevis Patriots who defeated St Lucia’s Kings by a whopping 137 runs – the biggest margin of victory in the CPL. Shanaka’s strike rate of 281.39 was also the highest for a century in the CPL. In his innings of 121* off 43 balls Shanaka slammed 8 fours and 12 sixes, with 4 sixes and a four coming off the final over of the innings. Amongst the bowlers who took a beating from Shanaka’s broad bat were Sri Lankan team mate Maheesh Theekshana who went for 48 runs, Matthew Forde, Joshua Bishop, Keon Gaston and Roston Chase.

T20I Squad (revised): Pathum Nissanka, Kamil Mishara, Lahiru Udara, Kamindu Mendis, Charith Asalanka (Captain), Pavan Rathnayake, Janith Liyanage, Dasun Shanaka, Dunith Wellalage, Wanindu Hasaranga, Maheesh Theekshana, Tharindu Rathnayake, Dushmantha Chameera, Eshan Malinga, Nuwan Thushara, Dilshan Madushanka.